Frameworks of Tampa Bay, originally the Ophelia Project, was founded in 2002 to address bullying and relational aggression in middle school girls. As a community initiative, it was headquartered under the umbrella of the YMCA of Tampa Bay. In response to community interest, the Boys Initiative was added in 2006 to address bullying and relational aggression in middle school boys as well.
In 2007, The Ophelia Project and the Boys Initiative merged to form OPBI, Inc., a 501(c)(3) organization. The organization continued its mission to meet the gender-specific needs of girls and boys through the delivery of bullying and violence prevention programming. The organization expanded its services to include elementary school girls by becoming the local council for Girls on the Run International. Same-gender high school social and emotional learning programs were offered as well.
On April 7, 2011, the organization announced its new name, Frameworks of Tampa Bay, Inc., and a new social mission: to teach youth to manage their emotions, develop healthy relationships, and make good decisions for academic, career, and personal success, to align with the national movement to make social and emotional learning (SEL) a key component of national education reform.